DanceTherParkinsonV1, Main, Exploration, bibRecord, 000102

Eph Receptor Signaling and Ephrins

Identifieur interne : 000102 ( Main/Exploration ); précédent : 000101; suivant : 000103

Eph Receptor Signaling and Ephrins

Auteurs : Erika M. Lisabeth [États-Unis] ; Giulia Falivelli [États-Unis, Italie] ; Elena B. Pasquale [États-Unis]

Source :

Cold Spring Harbor Perspectives in Biology [ 1943-0264 ] ; 2013.

RBID : PMC:3753714

Abstract

The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce signals from the cell exterior to the interior through ligand-induced activation of their kinase domain. However, the Eph receptors also have distinctive features. Instead of binding soluble ligands, they generally mediate contact-dependent cell–cell communication by interacting with surface-associated ligands—the ephrins—on neighboring cells. Eph receptor–ephrin complexes emanate bidirectional signals that affect both receptor- and ephrin-expressing cells. Intriguingly, ephrins can also attenuate signaling by Eph receptors coexpressed in the same cell. Additionally, Eph receptors can modulate cell behavior independently of ephrin binding and kinase activity. The Eph/ephrin system regulates many developmental processes and adult tissue homeostasis. Its abnormal function has been implicated in various diseases, including cancer. Thus, Eph receptors represent promising therapeutic targets. However, more research is needed to better understand the many aspects of their complex biology that remain mysterious.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753714

DOI: 10.1101/cshperspect.a009159
PubMed: 24003208
PubMed Central: 3753714

Affiliations:

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Danse-thérapie et Parkinson

Eph Receptor Signaling and Ephrins

Eph Receptor Signaling and Ephrins

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